The Competence Centre for Advanced BioProduction by Continuous Processing, AdBIOPRO, aims at developing competitive technology for bioproduction, focusing on the imminent paradigm shift towards continuous processes of biopharmaceuticals, and on manufacturing of emerging potent therapeutic products such as recombinant viral vector and cell products.

Driven by their complementary competence, academic expertise from five teams at KTH, covering mammalian cell bioprocessing (Docent Véronique Chotteau), cell omics characterization (Assistant Prof. Johan Rockberg), gene therapy (Prof. Torbjörn Gräslund), downstream processing (Prof. Sophia Hober) and data driven modelling and control (Prof. Håkan Hjalmarsson and Prof. Elling W Jacobsen), are joining forces with partners from Karolinska University Hospital (Associate Prof. Pontus Blomberg) and Lund University (Prof. Bernt Nilsson) and seven industrial partners, Swedish Orphan Biovitrum, Cobra Biologics, BioInvent, GE Healthcare Life Sciences, Valneva, Lab-on-a-Bead, and CellProtect Nordic Pharmaceutical to create a sustainable environment for this purpose. AdBIOPRO is co-funded by VINNOVA and the industrial partners.

Integrated continuous bioprocess Biopharmaceuticals have become the best selling drugs in terms of revenues, e.g. with monoclonal antibody sales, compared to small molecules. Beyond the supremacy of monoclonal antibodies, the actual trends are going towards growing pipelines of biopharmaceuticals, more complex protein drugs but also cell-based emerging alternative therapeutic approaches such as gene and cell therapy. In the domain of biopharmaceutical manufacturing, the legacy is fed-batch process (i.e. batch process fed with time) followed by several batch purification steps, e.g. chromatography steps, supported by in house industrial technology platforms. However the field is rapidly evolving by incorporating novel technologies to meet the challenges brought by the new trends and a constant need of competitiveness. In this perspective, continuous processes have recently received a very high interest. Integrated continuous bioprocesses consist of perfusion culture where medium is steadily added and harvest is removed to be processed in a purification process made of continuous consecutive steps.

Why continuous bioprocess for biologics production? This recent interest is rapidly increasing and it is clear that nearly all the large Pharma/Biotech companies are now looking into this type of intensified process. The drivers behind this new trend are several: the main one is the highly reduced need of capital expenditure due to potential high productivity in smaller bioreactors, other factors are better/more robust cell separation devices, high need of flexibility combined with increased use of disposable equipment, possibility to fine tune or control the product quality, reduced cost of resins for purification and declaration from FDA and EMA that biologics production should switch towards continuous processes.

Project team

The center is a collaboration between five teams and at KTH and partners from Karolinska University Hospital and Lund University and seven industrial partners.

Division of Decision and Control Systems KTH

Project funding and duration

The competence center, which is sponsored by VINNOVA, Sweden’s innovation agency, was launched in July 2017 and has an expected duration of 10 years.

Center website

Håkan Hjalmarsson
Professor of Signal Processing

My research interests cover system identification, process modeling and control, and communication network